For the majority of people with pain, their arthritic joint or disc space houses more destructive enzymes than the body can handle. Alpha-2-Macroglobulin, more commonly referred to as A2M, is our body’s own defense mechanism, but it too big and complex to enter the joint or disc space in large enough quantities. As a result, it is necessary to inject additional concentrated A2M into the affected area to restore balance and relieve pain.